New Aspects of Neurotransmitter Releasee and Exocytosis: Regulation of Neurotransmitter Release by Phosphorylation
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چکیده
منابع مشابه
Regulation of neurotransmitter release by synapsin III.
Synapsin III is the most recently identified member of the synapsin family, a group of synaptic vesicle proteins that play essential roles in neurotransmitter release and neurite outgrowth. Here, through the generation and analysis of synapsin III knock-out mice, we demonstrate that synapsin III regulates neurotransmitter release in a manner that is distinct from that of synapsin I or synapsin ...
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Synapsin I is a synaptic vesicle-associated protein that is phosphorylated at multiple sites by various protein kinases. It has been proposed to play an important role in the regulation of neurotransmitter release and the organization of cytoskeletal architecture in the presynaptic terminal. In the present minireview, I describe the dynamic changes in synapsin I phosphorylation induced by acute...
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BACKGROUND The immunophilins are proteins that mediate actions of immunosuppressant drugs such as FK506 and cyclosporin A by binding to calcineurin, inhibiting its phosphatase activity, and increasing the phosphorylation level of transcription factors required for interleukin 2 formation. Though concentrations in the brain greatly exceed levels in immune tissues, no function has been previously...
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Serotoninergic neurons in the central nervous system impinge on many other neurons and modulate their neurotransmitter release. This review focuses on 1) the function of presynaptic 5-hydroxytryptamine (5-HT) heteroreceptors on axon terminals of central cholinergic, dopaminergic, noradrenergic, or GABAergic neurons and 2) the role of GABAergic interneurons expressing 5-HT heteroreceptors in the...
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Retzius cells are large neurons in the ganglia of the leech (Lent, 1977), releasing 5-HT (Leake, 1986) and orchestrating the animal behavior (Carretta, 1988). The leech nervous system is relatively simple and its exploration allows correlating, in a quantitative manner, the chemical and electrical activity, at cellular level, with the animal behavior (Mazzoni et al., 2007). The recent work of F...
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ژورنال
عنوان ژورنال: Journal of Pharmacological Sciences
سال: 2003
ISSN: 1347-8613,1347-8648
DOI: 10.1254/jphs.93.41